In modern healthcare facilities, infection control protocols are essential for patient safety. Filipino nurses working in international hospitals must understand that hand hygiene is the most critical factor in preventing healthcare-associated infections (HAIs). According to the World Health Organization, proper handwashing can reduce infection rates by up to 50%. In Philippine hospitals, nurses like Maria Santos have implemented the '5 Moments for Hand Hygiene' protocol, which requires hand sanitization before patient contact, before aseptic procedures, after body fluid exposure, after patient contact, and after contact with patient surroundings.